GW501516 (Cardarine) doesn’t have any published human studies. In rodents, though, it shows great promise as an exercise mimetic – it lights up many of the same genes you’d activate by going on a run or lifting . That alone wasn’t enough to make much of a change, but when researchers had mice take GW501516 with consistent exercise, results went through the roof:
In mice, GW501516 combined with 4 weeks of regular running increased running time by 68% and running distance by 70%, and doubled overall muscular endurance .
In rodents, GW501516 plus exercise increased mitochondrial growth in muscle by ~50% , allowing muscles to generate more power without fatiguing.
It also decreased fat while preserving muscle (again, in mice)
GW501516 could be a powerful way to improve performance and shed fat while maintaining muscle.
(andarine) was the earliest SARM. It was popular in the 2008 Olympics, before SARMs were banned from professional athletics. Users report modest strength and muscle gain, as well as modest fat loss.
S4 seems to work best if you use it alongside other SARMs. It pairs well with MK-2866 and LGD-4033. Both suppress testosterone at higher doses, a side effect S4 can counter.